Download Advances in Human Genetics 11 by Magne K. Fagerhol, Diane Wilson Cox (auth.), Harry Harris, PDF

By Magne K. Fagerhol, Diane Wilson Cox (auth.), Harry Harris, Kurt Hirschhorn (eds.)

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1979). This condition is also associated with HLAB27, ankylosing spondylitis, and fibrosing alveolitis. Further studies will be required to clarify these associations. , 1975).

18 Magne K. Fagerhol and Diane Wilson Cox A linkage of acid phosphatase (ACP) on chromosome 2 to Gm-Pi was not supported by further data (Noades and Cook, 1976). , 1975). Gm and dominant spherocytosis are possibly linked, with 30% recombination (Noades and Cook, 1976). In summary, the Gm-Pi linkage group may be on chromosome 6, 8, or 12. ) Selective Mechanisms The Z allele is polymorphic in most populations, in spite of its reduction of fitness for homozygotes. This is suggestive of a selective advantage for heterozygotes.

Fagerhol and Diane Wilson Cox Antigenicity All the u )AT variants discovered up to now carry a common antigenic determinant, as judged from their reactions with antisera from commonly used experimental animals such as rabbit, goat, sheep, and pig. In no instance has isoimmunization against u)AT been reported in man. Several laboratories have tried to prepare specific antibodies against the Z protein and other variants, but without success. One might suspect that even if such antibodies were made by animals they would probably have been overlooked, since the commonly used immune-precipitation methods in gels require that each antigenic molecule carries at least two antigenic determinants of the same type.

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