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By Rodolfo Paoletti, Dr. David Kritchevsky

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KUKSIS that further differences and/or similarities could have been detected if comparisons of molecular species of glycerophospholipids had been made among individual cell types. 3. Variations in Subcellular Distribution As would be expected from the fatty acid compositions presented in Section ΙΙ,Α, striking differences as well as similarities are evident when comparisons are made among molecular species of glycerophospholipids from different subcellular fractions such as microsomes, mitochondria, plasma membranes, and other cellular organdíes.

Only certain molecular species of specific glycerophospholipids have been shown to possess pronounced micellar properties under physiological ranges of concentration, pH, and ionic strength. Although micelle formation may be one of the major results of the physiological action of glycerophospholipids, such a function for these molecules in living systems has been specifically recognized in only a few instances. It is well established that the bile from all animal species is rich in phos­ phatidylcholine which exists in micellar solution and functions as a deter­ gent.

1970) on a surface active fraction from dog lung, which contained lipid, protein, and carbohydrate, indicated that the surface Metabolism of Diacylglycerophospholipids 43 properties of this fraction could not be explained solely from a consideration of the properties of dipalmitoylphosphatidylcholine. Furthermore, Munden and Swarbrick (1973) have shown that the surface films of lung alveolar surfactant consistently demonstrate a greater stability than those of dipal­ mitoylphosphatidylcholine even though the latter is a major component of lung alveolar surfactant.

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