By Jolieke C. van der Pols (auth.), Reinhard Dummer, Mark R. Pittelkow, Keiji Iwatsuki, Adèle Green, Nagwa M. Elwan (eds.)
The dramatic elevate within the occurrence of dermis cancers is an incredible obstacle around the globe and relates not just to cancer but in addition to different cancers, together with Merkel phone and basal phone carcinomas. lately, the WHO has summarized the genetic and pathologic good points of dermis cancers in its publication sequence. in spite of the fact that, the WHO’s proposed class of yes affliction entities, similar to basal telephone carcinomas, remains to be novel for plenty of dermatologists. This e-book covers the whole spectrum of cutaneous malignancies in response to the recent WHO category. Epidemiology, pathogenesis, analysis, and treatment are all reviewed intimately, and care is taken to hyperlink the diagnostic and genetic good points to optimized healing options. so as to mirror the global actions within the box, the editors have introduced jointly top researchers and clinicians from each continent to speak their person reviews and services. the result's a distinct compilation of present clinical and molecular wisdom approximately dermis cancers. it really is expected that this booklet will stay a uncomplicated reference for a few years to come.
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Extra resources for Skin Cancer - A World-Wide Perspective
Childhood sun exposure as a risk factor for melanoma: a systematic review of epidemiologic studies. : The role of sunlight and DNA repair in melanoma and nonmelanoma skin cancer. The xeroderma pigmentosum paradigm. Arch. Dermatol. : Cutaneous malignant melanoma in association with other skin cancers. J. Natl. Cancer Inst. : Incidence of invasive cancers following squamous cell skin cancer. Am. J. Epidemiol. : Risk of cutaneous melanoma associated with pigmentation characteristics and freckling: systematic overview of 10 case-control studies.
Because MC1R genotypes are associated with both red hair and skin type, and because these characteristics are both associated with increased risks of melanoma, a logical extension was to test for an association between MC1R genotype and melanoma. 5 for seven of the nine MC1R variants tested . 84). Unfortunately, that meta-analysis could not assess the effects of MC1R independently of the effects of other pigmentation characteristics, and so the magnitude of the risk estimates must be interpreted with caution.
The role of nevi as risk markers, and possible precursors, for melanoma is discussed in more detail below (Sect. 3). 4 Artificial Sources of Ultraviolet Radiation Because of the ecological and analytical studies linking sun exposure to melanoma and the conclusion that the carcinogenic component of sunlight is UV radiation, one would infer that artificial sources of UV radiation exposure (such as sunbeds and tanning lamps) are also potential causes of melanoma . In a recent systematic review, ten studies were identified (nine case–control; one cohort) that addressed this hypothesis and provided relevant estimates of risk .